Cabometyx

Cabometyx overview

• Brand name: Cabometyx

• Active ingredient: cabozantinib (as S‑malate)

• Dosage forms: film‑coated tablets, commonly 20 mg, 40 mg and 60 mg

• Prescription: prescription‑only medicine, started and monitored by an oncologist or specialist

• Therapeutic class: targeted multikinase inhibitor (anticancer medicine)

Cabometyx works by blocking specific enzymes (tyrosine kinases) involved in tumour growth, blood vessel formation and cancer spread. This helps slow the progression of advanced cancers and may help control symptoms and improve disease outcomes.

What Cabometyx is used for

Your doctor may prescribe Cabometyx for:

• Advanced kidney cancer (renal cell carcinoma)

  • Used alone in adults with advanced kidney cancer

  • Used together with another cancer medicine (such as nivolumab) as a first‑line treatment in some patients

• Liver cancer (hepatocellular carcinoma)

  • Used in adults with liver cancer that has progressed after previous systemic treatment

• Certain thyroid cancers

  • Used in adults and some adolescents with advanced differentiated thyroid cancer that has spread or progressed and is no longer responding to radioactive iodine treatment

Always follow your cancer specialist’s advice and local prescribing information, as approved uses can vary by country.

How to take Cabometyx

• Take Cabometyx exactly as prescribed by your doctor.

• Usual dosing is once a day, at about the same time each day.

• Swallow the tablet whole with a glass of water. Do not crush, chew or split the tablet.

• Take Cabometyx on an empty stomach:

  • At least 1 hour before food, or

  • At least 2 hours after food.

If you miss a dose and the next dose is due in less than 12 hours, skip the missed dose and take your next dose at the usual time. Do not take a double dose to make up for a forgotten tablet.

Your doctor may change your dose or temporarily stop treatment if you experience side effects. Never adjust the dose yourself without medical advice.

Important safety information

Cabometyx is a powerful targeted cancer medicine and can cause side effects. Your healthcare team will monitor you regularly with blood tests, blood pressure checks and clinical reviews.

Common side effects can include:

• Diarrhoea, nausea, vomiting, constipation or abdominal pain

• Loss of appetite, weight loss or changes in taste

• Fatigue or weakness

• Mouth sores or inflammation (stomatitis)

• Skin changes, including redness or soreness on the hands and feet (hand–foot skin reaction), rash or dry skin

• High blood pressure

• Changes in blood tests (liver, kidney, thyroid function, blood counts, electrolytes)

Serious side effects – seek urgent medical help if you notice:

• Signs of severe bleeding: coughing or vomiting blood, black or bloody stools, severe nosebleeds

• Sudden chest pain, shortness of breath, severe headache, confusion, weakness on one side of the body (possible blood clot, stroke or heart problem)

• Severe or persistent abdominal pain, fever, vomiting (possible perforation or fistula in the gut)

• Very high blood pressure with severe headache or visual changes

• Jaw pain, swelling, loose teeth or poor healing after dental work (possible jaw bone problems)

Tell your doctor immediately if any side effects worry you, become severe, or if you notice anything else that makes you feel unwell.

Before using Cabometyx

Tell your doctor or pharmacist if you:

• Have high blood pressure, heart problems, blood clotting disorders or a history of stroke

• Have liver problems or kidney problems

• Have a history of bleeding, stomach ulcers, bowel problems or perforation/fistula

• Are due to have surgery, including dental surgery (Cabometyx may need to be stopped before and after major procedures)

• Are pregnant, planning a pregnancy or breastfeeding

Cabometyx is not recommended during pregnancy and breastfeeding. Effective contraception is usually required during treatment and for some time after the last dose, as advised by your doctor.

Interactions with other medicines

Cabometyx can interact with many other medicines. Tell your doctor or pharmacist about all medicines you are taking, including:

• Prescription medicines

• Over‑the‑counter medicines

• Herbal remedies and supplements (especially St John’s wort)

Some antibiotics, antifungals, epilepsy medicines, HIV medicines and products like St John’s wort can change how Cabometyx is processed in your body. Blood thinners (anticoagulants), antiplatelet agents and NSAIDs may increase bleeding risk. Avoid grapefruit and grapefruit juice during treatment unless your doctor advises otherwise.

Storage and handling

• Store Cabometyx below the temperature stated on the pack (commonly below 25 °C).

• Keep tablets in the original packaging to protect from moisture and light.

• Keep out of the sight and reach of children.

• Do not use after the expiry date shown on the carton or blister.

• Return any unused or expired tablets to your pharmacy for safe disposal.

Why order Cabometyx from Waldrugmart Online Pharmacy

• Genuine, pharmacy‑dispensed Cabometyx from trusted, regulated suppliers

• Professional pharmacist support to answer treatment and safety questions

• Discreet, secure packaging and convenient delivery

• Easy repeat ordering for ongoing cancer treatment, in line with your current prescription

Cabometyx can only be supplied with a valid prescription from your doctor. To add Cabometyx to your order at Waldrugmart Online Pharmacy, please upload your prescription, and our pharmacist team will verify it before dispensing.